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Bioanalysis & LC-MS

Sensitive, reproducible quantification of drugs and biomarkers in plasma and tissue — inert-hardware columns for stronger MS signal, isotope-labelled internal standards, and automated immunoassays for large molecules.

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Who uses it

Bioanalytical CROs, DMPK and clinical pharmacology labs, and BA/BE study centres.

Partners in this workflow
Welch MaterialsTLC Pharmaceutical StandardsBio-Techne

Challenges we help solve

Challenge 1Weak MS signal

Metal-sensitive analytes adsorb to steel hardware, losing sensitivity and peak shape.

Challenge 2Matrix effects

Plasma and tissue matrices suppress ionisation without a matching internal standard.

Challenge 3Large-molecule bioanalysis

Biologics and biomarkers need fast, low-volume immunoassays.

The workflow, step by step

  1. 1Internal standards

    Pick isotope-labelled analogues of each analyte.

    TLC stable isotope-labelled standards
  2. 2Separation

    Inert, high-efficiency columns for LC-MS/MS.

    Welch DLC · Boltimate® · UHPLC
  3. 3Validation

    Accuracy, precision and stability to regulatory guidance.

    TLC reference standards with CoA
  4. 4Large molecules

    Quantify biologics and biomarkers.

    Bio-Techne Simple Plex Ella · ELISA

Recommended products

7 products for this workflow. Click a picture for a quick view, or add products to your quote list.

Quote the whole workflow

Tell us your analyte, matrix and current method.

Related applications

Pharma QC & impurity analysis Protein & cell biology research Biologics developability