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Biologics developability & formulation

Pick candidates that will survive manufacturing and storage. Screen stability, aggregation, viscosity, charge variants and particles early — using microlitres of material.

Who uses it

Antibody discovery, formulation development and analytical teams at biopharma companies and CROs.

Partners in this workflow
Unchained LabsBio-TechneFlowCamWelch Materials

Challenges we help solve

Challenge 1Too little material

Early candidates exist in microgram quantities, but need many measurements.

Challenge 2High-concentration formulations

Subcutaneous products push viscosity and aggregation limits.

Challenge 3Too many candidates

Screening dozens of molecules and buffers manually is slow and inconsistent.

The workflow, step by step

  1. 1Concentration & size

    Measure concentration and hydrodynamic size together.

    Unchained Stunner, Lunatic
  2. 2Thermal & colloidal stability

    Rank candidates by melting and aggregation onset.

    Unchained Aunty
  3. 3Viscosity & buffer screens

    Test formulations at high concentration.

    Unchained Honeybun, Lil’ Tuna
  4. 4Charge & purity

    Profile charge variants and size purity.

    Bio-Techne Maurice, Simple Western
  5. 5Particles

    Image subvisible particles after stress.

    FlowCam 8000, Nano

Recommended products

9 products for this workflow. Click a picture for a quick view, or add products to your quote list.

Quote the whole workflow

Tell us your molecule type and what you need to measure.

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