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Oligonucleotide, mRNA & peptide manufacturing

From solid-phase synthesis to purified, concentrated and formulated product — synthesizers, prep chromatography, TFF and LNP assembly that scale from lab to pilot to production.

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Who uses it

CDMOs, API manufacturers and biotech teams developing antisense, siRNA, mRNA vaccines and therapeutic peptides.

Partners in this workflow
InscinstechWelch MaterialsUnchained Labs

Challenges we help solve

Challenge 1Scaling synthesis

Processes developed on lab synthesizers must move to pilot and GMP scale without re-work.

Challenge 2Purity of full-length product

Removing failure sequences and closely related impurities needs high-resolution prep chromatography.

Challenge 3Consistent LNP formulation

Particle size and encapsulation must be reproducible from screening to production.

The workflow, step by step

  1. 1Synthesis

    Solid-phase oligo synthesis at lab or pilot scale.

    Inscinstech synthesizers · oligo columns & supports
  2. 2Purification

    Prep HPLC to isolate full-length product.

    Inscinstech prep HPLC · Welch prep & DAC columns
  3. 3Concentration & desalting

    Buffer exchange and concentration before formulation.

    Inscinstech TFF systems
  4. 4LNP formulation

    Encapsulate mRNA or siRNA in lipid nanoparticles.

    Inscinstech assembly · Unchained Sunscreen/Sunshine
  5. 5Characterization

    Concentration, size and encapsulation checks.

    Unchained Lunatic, Stunner AF

Recommended products

9 products for this workflow. Click a picture for a quick view, or add products to your quote list.

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Related applications

Downstream purification Cell & gene therapy Pharma QC & impurity analysis