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Upstream cell culture (CHO)

Higher antibody titres start with the right media and a well-controlled bioreactor. Pair CELLiST basal media, feeds and supplements with lab-scale bioreactors for process development.

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Who uses it

Biosimilar and innovator mAb developers, CDMOs and vaccine manufacturers running CHO fed-batch processes.

Partners in this workflow
Ajinomoto CELLiST KoreaInscinstech

Challenges we help solve

Challenge 1Plateauing titres

Generic media limit productivity; switching platforms needs data on your own clone.

Challenge 2Complex feeding regimes

Multiple feeds and pH adjustments add risk and operator workload.

Challenge 3Process development capacity

Teams need small-scale bioreactors that mimic production conditions.

The workflow, step by step

  1. 1Media screening

    Compare basal media on your CHO clone at small scale.

    CELLiST BASAL3, BASAL10, BASAL CHO MX
  2. 2Feed strategy

    Define a fed-batch feeding regime.

    CELLiST FEED2, F7
  3. 3Supplement & optimise

    Fine-tune amino-acid balance for growth and titre.

    AminoSupplement · Glycyl-L-Tyrosine
  4. 4Bioreactor runs

    Confirm the process in controlled bioreactors.

    Inscinstech lab bioreactors

Recommended products

6 products for this workflow. Click a picture for a quick view, or add products to your quote list.

Plan a media evaluation

Share your cell line and current platform.

Related applications

Downstream purification Biologics developability Cell & gene therapy